Pipeline & Platform
Acelot is advancing a pipeline of novel small-molecule therapies for diseases with limited treatment options. Our work is powered by Resolute, an integrated drug-discovery platform that combines advanced AI-driven computational tools with deep biological insight to tackle complex protein targets that have historically been difficult to drug.
* Acelot is pursuing targets that have demonstrated potential applicability in a range of neurodegenerative diseases, including TDP-43 positive fronto-temporal dementia, Alzheimer's disease (AD), inclusion body myositis, multiple system atrophy, and dementia with Lewy bodies.
ACE-2223
Our lead candidate is ACE-2223, a small molecule specifically designed to target misfolded TDP-43 and restore its healthy form and function. By addressing the root cause of ALS pathology, ACE-2223 has the potential to slow or halt disease progression where no approved therapies currently exist.
Resolute Platform
Resolute is an integrated drug-discovery platform that combines four specialized components working together to turn early scientific ideas into drug candidates ready for clinical development.
The process begins with PHILEO, which searches vast libraries of compounds to identify promising starting points and refines them into better drug candidate leads. AMORA then predicts the 3D structure of proteins, while COEUR works closely alongside it, running dynamic simulations to reveal how drug molecules move and bind their targets. Running throughout the entire workflow, BEATS uses computational biology to identify disease targets, map biological pathways, and evaluate biomarkers from the earliest stages all the way to clinical development.
Together, these four components create a continuous, end-to-end workflow that helps our team discover and advance new drug candidates in challenging targets and diseases where existing treatments fall short or are absent.
PHILEO: HIT FINDING
PHILEO performs algorithmic hit identification across large chemical libraries, supporting the full hit-to-lead and lead-optimization stages of the medicinal chemistry pipeline.
AMORA: PROTEIN STRUCTURE PREDICTION
AMORA generates high-resolution protein structure predictions, used in concert with COEUR to inform binding analysis and rational ligand design.
COEUR: MOLECULAR DYNAMICS
COEUR executes coarse-grained molecular dynamics simulations to model protein–ligand conformational interactions and binding trajectories. It operates in tight integration with AMORA to guide iterative compound optimization.
BEATS: COMPUTATIONAL BIOLOGY
BEATS applies computational systems biology to perform target identification, pathway mapping, and biomarker evaluation across the discovery-to-clinical continuum.